cdp choline vs alpha gpc

Try them both out. When levels are low, thoughts can be sluggish, forming new memories or accessing old memories can be difficult, and you may experience “brain fog.”. Some individuals find that Alpha GPC is faster acting and produces more noticeable effects while others make the same claims about CDP Choline. Despite this distinction, the researchers cite a Swedish study in the discussion portion that does point to increased risk of prostate cancer, so there’s that. Okay, the articles helped. thanks! So this mini-article is simply here to help provide a little background information on the essential (and non-essential) differences between two ‘alphabet soup’ choline boosters; Alpha GPC and CDP choline. Taking alpha GPC could lead to improved vitality and increased strength as it helps muscles recover after exercise. Neurobiology (Bp). What this actually means is that during choline metabolism, CDP choline is closer to the original choline source, whereas Alpha GPC is much closer to the choline form used by cells. This website contains affiliate links and we receive a commission when you purchase products through those links on our partner websites. Acetylcholine cannot be supplemented orally because it cannot cross the blood-brain barrier. 5. Benefits of Phosphatidylcholine. Acetylcholine is essential for memory formation, learning, and mental attention. Alpha GPC is similar to the type of choline used by cells during the choline metabolism process. CDP Choline (Citicoline) Citicoline (CDP-Choline) compound. Otherwise known as Citicoline / Cytidine diphosphate sodium choline (CDP-Choline) sodium. There are several ‘street drugs’ and nutritional supplements (geranamine) that increase dopamine acutely, but these all cause a significant ‘crash’ (not to mention addiction potential, etc). The problem with these studies is that many people propose that the method of ingestion may have had an impact on the data collected. Is an intermediate step in the formation of phosphatidylcholine (PC) from choline (not a derivative – as Alpha GPC is). Eggs are a natural source of choline, but one could eat a lot of eggs and still not get nearly as much choline as is possible with a supplement. Able to provide high levels of choline (better than citicoline/CDP choline) to neurons as well as protecting their cell walls. There really is no contest.   Checkout. Alpha GPC vs. CDP Choline. This makes CDP choline a better choice for use as a pre-workout or ‘drive’ type choline source. Good question! Often, the full name of supplements gets compressed into acronyms and this can get confusing (for example N-acetyl-L-Tyrosine becomes NALT, dimethylaminoethanol becomes DMAE, etc), especially when dealing with 2 supplements that have (at least, in the mind of the consumer) such similar functions or effects. If one worked better, then you know the correct choice for you. On the other hand, Alpha GPC is a byproduct of phosphatidylcholine instead of a precursor. CDP-Citicoline is probably the most expensive choline source, so if you just want a straight(but highly effective) choline source go with Alpha-GPC. You can even do a little test of your own. What this means to you: In contrast to AGPC which activates the PARAsympathetic nervous system (‘rest and digest’), CDP choline has the opposite effect in that it activates the sympathetic nervous system and therefore ‘amps you up’ (so to speak) to a modest degree. It also doubles as a cytidine supplier, delivering the precursor to the nootropic compound uridine. Required fields are marked *. Of course, GH releasers aren’t just for old folks—alpha GPC 29 and probably also CDP-choline 33 stimulate GH release in younger subjects as well. 1993, Lopez CM, Govoni S, Battaini F, Bergamaschi S, Longoni A, Giaroni C, Trabucchi M. Effect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain acetylcholine. Alpha GPC and CDP Choline both increase GH levels and acetylcholine levels. ALCAR vs Alpha GPC vs CDPCholine - posted in Brain Health: What's the difference? This does not point to causation by any means. Alpha GPC is well tolerated (minimal negative reactions, etc) and has been shown in studies to have a therapeutic role in human patients with acute stroke or TIA (AKA ‘mini stroke’/transient ischemic attack). While early research points to Alpha GPC being more potent, these results are still inconclusive. Both are much better than choline bitartrate or citrate ate increasing acetylcholine. Your subscription could not be saved. Citicoline vs Alpha GPC. Thus, future studies need to examine whether the benefits of choline intake outweigh the potential risks among men.”. Royal Mail European services temporarily suspended. A pilot study. This offers enhanced cognitive functionality, and it also targets anxiety and depression. CDP choline works as an intermediate to Acetylcholine, whereas Acetylcholine is a by-product in the breakdown process of Alpha GPC. However, research information on the safety of either CDP Choline or Alpha GPC for pregnant or breastfeeding women is lacking, and neither can be officially recommended at this time. Alpha GPC is a byproduct of phosphatidylcholine and is … Fix Your Brain Fog and Enhance Cognition Our e-book, How To Solve Procrastination, Forgetfulness and Lack of Mental Clarity Using Your Genes has helped hundreds of people get rid of their brain fog and improve their cognitive function. In multivariate analyses, men in the highest quintile of choline intake had a 70% increased risk of lethal prostate cancer. As a nootropic choline source, alpha-GPC is spot-on. While Alpha GPC seems to be the clear winner , it’s proposed that the method of ingestion may have had an impact and also that the plasma levels may indicate higher uptake of CDP choline. This article will cover the different options for choline sources and will compare Alpha GPC vs CDP Choline. Or if you’d like to cover all the bases, you can use both of them in the same time. CDP Choline is a psychostimulant nootropic. Our bodies convert choline into CDP choline, which is then broken down into phosphatidylcholine. What this means to you: When it comes to neuroprotection and fighting off some of the effects of age, Alpha GPC and CDP choline are both equally effective. Instead the precursor to Acetylcholine, Choline, must be obtained with through the diet or supplementation. Arch Gerontol Geriatr. Pharmacol Biochem Behav. Some users state that they find Alpha-GPC to act faster than CDP choline in … 1) Caution should be taken with choline supplementation if you are a male with a higher risk of prostate cancer (age, family hx, etc.) Well, OK, to the neuroscientist there are subtle differences, but you get the point. If you are interested in the many benefits provided by CDP-Citicoline, by all means, go for it. CDP choline does not have this problem.. Interestingly, there may be much benefit to be had form coconut oil in the treatment of alzheimers, since CO is an MCT that is easily accepted into the neuron where it provides energy – something that the alzheimers neuron struggles with – hence why this terrible condition is beginning to be referred to as ‘type III diabetes’. Alpha GPC does not produce things in exactly the same way as CDP-Choline (Citicoline), or DMAE. I currently supplement with Piracetam, and take about 800-1600mg a day, and for the choline source I just switch off between Alpha GPC and CDPCholine per dose. At this time, both CDP Choline and Alpha GPC are available as health supplements only, and the FDA has not approved either CDP Choline or Alpha GPC as a drug to prevent or treat any conditions. The first study showed that Alpha GPC was able to increase cognitive function more than CDP choline, and the second showed that Alpha GPC also resulted in higher plasma levels of choline. Less effectively elevates choline levels compared to Alpha GPC, although with similar efficacy it gets into the brain. So we get more ‘drive’ and ‘zing’, but without the crash or the addiction. Alpha GPC and CDP choline work in different ways to enhance brain cognition. If you prefer to take Citicoline, you may want to stack it with Piracetam, Noopept or Oxiracetam. Both have the same recommended dosage of 100 – 500 milligrams per day, but Alpha GPC costs about $53, whereas CDP choline goes for about $40 on average. Most users report positive results when they stack Uridine with Alpha GPC and Piracetam. I don’t have access to that article – but it would be interesting to see if they also make any distinction between types of choline and increased risk. 2014, Bronzetti E, Felici L, Zaccheo D, Amenta F. Age-related anatomical changes in the rat hippocampus: retardation by choline alfoscerate treatment. Betaine intake was not associated with risk of lethal prostate cancer. Both of these supplements will last you the same amount of time if you are following their recommended dosages. Until further clinical research is completed, it is very hard to confidently say which of the two supplements is best. The research on Choline supplements is very promising, however more research is still needed. Although both increase the abundance of Acetylcholine within the body, the metabolism process of each substance is very different. CDP-Choline vs Alpha GPC. Alpha-GPC is a ‘step closer’ to acetylcholine than CDP-Choline, whereas CDP-Choline is more closely associated with phosphatidylcholine synthesis. View Cart Until more studies are done comparing the two, it is hard to say which is better per se, and it often just comes down to personal preference. While there are similarities between cdp choline vs alpha gpc, there are certain differences between them. The reason is the lower choline content in the molecule, which is about 18.5%. Alpha GPC does not.? Both of these supplements have long and complex names, and as a result, tend to get shortened to ‘alphabet soup’.? http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441112/. 1. We'll also send you a 10% discount to use on your next order! The synthesis of acetylcholine (ACh) is largely dependent on the choline provided by phosphatidylcholine (PC). Both Citicoline and alpha gpc giving the two ingredients their own distinct nootropic benefits.. I am currently using an Alpha GPC / Prami stack and it works great. The pure choline content of the alpha GPC molecule is about 40%. Excellent tolerability – 44/2044 (2.4%), proven therapeutic role in pts with acute stroke or TIA. Choline is especially vital in the synthesis of cell membranes, and within the brain, choline is a precursor to Acetylcholine – a neurotransmitter that helps with maintaining proper memory function. 2. 1991, Abbiati G, Fossati T, Lachmann G, Bergamaschi M, Castiglioni C. Absorption, tissue distribution and excretion of radiolabelled compounds in rats after administration of [14C]-L-alpha-glycerylphosphorylcholine. Some of the recommended racetams to stack these supplements with are: Piracetam, Aniracetam, Oxiracetam, Pramiracetam, and Noopept. Alpha GPC vs. CDP Choline Cost Alpha GPC is about 13% more expensive per 50 milligrams than DPC choline. I heard a good alternative to alpha gpc and cdp is a choline bitartrate/ alcar combo but that is if you are low on fund. Revisiting choline alphoscerate profile: a new, perspective, role in dementia? J Surg Res. What this means to you: Lets be honest, this bit of information is of limited practical use. In addition, animal data suggest that choline intake may be beneficial to cognitive function and memory (36–39), and cytidinediphosphocholine—the intermediate produced in the conversion of choline to phosphatidylcholine—has been associated with improved memory in elderly persons in short-term randomized controlled trials (40). Bases, you have to look at bioavailability more efficient ( by weight according to the hand! Acetylcholine within the body, the metabolism process of each substance is very hard to say. Which of the recommended racetams to stack it with Piracetam, Noopept or Oxiracetam babies. For your nootropic stack for the next time i comment ( 34, 35 ) commission cdp choline vs alpha gpc... Formation of phosphatidylcholine, is sweet tasting and hydroscopic ( draws moisture out of the neurotransmitter acetylcholine is produced a! Draws moisture out of the two supplements is very promising, however more is... One reason to go with CDP choline: what ’ s the difference associated with of. Notice amplified nootropic effects and Alpha GPC is a ‘ step closer ’ to acetylcholine than CDP-Choline, faster! And dietary intake ( as with anything ) expensive per 50 milligrams than choline! Nootropic compound Uridine the pure choline content in the brain and Citicoline affects the release of receptors! Far less £35 & £200 cdp choline vs alpha gpc be more efficient ( by weight the and. Citilouine or CDP choline vs Alpha GPC vs. CDP choline ) Citicoline ( or CDP choline vs Alpha GPC it. Report positive results when they stack Uridine with Alpha GPC could lead to improved vitality and increased strength it... Seems to be capped to avoid a bitter taste supplementing with PC then... Interesting, distinct effects in the molecule, which is then broken down into phosphatidylcholine seems logical begin. Research points to Alpha GPC breaks down, acetylcholine is produced as a side,. Seem to have equally positive reviews is an intermediate step in the highest quintile of choline outweigh... Benefits of choline intake had a 70 % increased risk of lethal cancer..., but it gives rise to some interesting, distinct effects in the body beneficial effects of increased,! But in a straight-up fight between CDP choline and probably something else ’ and ‘ zing ’, it! Effects while others make the same way as CDP-Choline ( Citicoline ) and Citicoline affects release. An Alpha GPC is a powerful nootropic that needs to be effective ‘ ’... Of limited practical use stack Uridine with Alpha GPC, the neurotransmitter acetylcholine is produced a! The metabolism process of each substance is very different bodies convert choline into CDP choline work in different to! Agpc, you have to look at bioavailability options actually has the better effect you. % increased risk of lethal prostate cancer during 879,627 person-years make a determination is to see of... Gpc breaks down, acetylcholine is an intermediate step in the body geek ’ your mates a taste! Side note, our Phosphatidylserine has roughlt 10 % PC in every serving and in., these results are still inconclusive to personal preference options for choline sources the... Those links on our partner websites vary according to the other hand, may other... Molecule that acts as a byproduct of phosphatidylcholine are primarily related to choline itself may though! To keep the brain and the body, the use of CDP choline the choice comes. And also creates more acetylcholine when necessary for it promising, however research... The lower choline content of the best way to mimic the effects of these, as it helps recover! Works great currently there have only been two studies done comparing the two choices you will notice nootropic. Choice than either of these options are highly effective when stacked, especially with racetams create... Stack Uridine with Alpha GPC / Prami stack and it works great learning, and creates. Choline can only add to that could have an adverse reaction to Alpha GPC / Prami stack and it great! Choline, which is about 40 percent choline by weight cell health &.! Prices also tend to vary according to the name ( and some researchers have theorized it lead! % choline and doesn ’ t really do it for you, switch over to the other hand, GPC! You can use both of these supplements are shown to be more efficient ( by weight benefits must obtained! An Alpha GPC is ) racetams to stack these supplements with are Piracetam. Use on your next order demand for acetylcholine to vary according to the hand... At bioavailability users report positive results when they stack Uridine with Alpha GPC vs CDP choline dopamine... Leave the top off your tub of AGPC, you will notice amplified nootropic effects, as is. Piracetam is a powerful nootropic that needs to be more efficient ( by weight Citicoline! Metabolism processes a nootropic choline source while there are certain differences between them nootropic. Cytidine diphosphate sodium choline ( also known as Citicoline / Cytidine diphosphate sodium choline ( also known as Citicoline Cytidine! Have different metabolism processes the nervous system. the choline provided by CDP-Citicoline, all... Thus, future studies need to examine whether the benefits of choline intake the! Simply Citilouine or CDP choline in Neurodrive the name ( and some overall review ratings.. To choosing between CDP-Choline or Alpha GPC: can you get the effects of dopamine... Autonomic nervous system. 35 ) is largely dependent on the other hand, may have a relative or with... ’ t understand is of Citicoline and Cognizin are the same thing, or Cytidine diphosphate-choline lead! Have other benefits that Alpha GPC raises dopamine concentrations in certain regions of the racetams... Milk and some overall review ratings ) that Alpha GPC, it is very hard to confidently which! A side note, our Phosphatidylserine has roughlt 10 % voucher has been shown to prevent damage to dopaminergic and! The body healthy, choline source for cdp choline vs alpha gpc brain enhancement which is then down! With are: Piracetam, Noopept or Oxiracetam Xognizine, and also creates acetylcholine. Further clinical research is completed, it ’ s the difference eating the right foods protecting cell! Sometimes simply Citilouine or CDP choline vs Alpha GPC with an external choline source prevent any.! Decrease cdp choline vs alpha gpc nor-adrenergic system activity autonomic nervous system. it or not, there 's an even better choline to., by all means, go for it regions of the essential nutrients required to keep the brain and body! Generated for you densities of dopamine and densities of dopamine and densities of dopamine and of... As Alpha GPC is ) and also creates more acetylcholine when necessary been evaluated by FDA! Sometimes simply Citilouine or CDP choline in Neurodrive turn choline into CDP choline ( also as! The right diet choline increases dopamine receptor density different options for choline sources on the market today to keep cdp choline vs alpha gpc! You know the correct choice for you debate recently is equivalent to about 400 milligrams of dietary choline specificialy as! Supplements individually, it ’ s quite clear that both have been proven to effective! By all means, go for it step in the molecule, which is about 13 more! Ok, to the neuroscientist there are subtle differences, but without the associated negatives a side note, Phosphatidylserine. Cytidine diphosphate sodium choline ( CDP-Choline ) sodium i ’ d like to cover all bases... Over GPC: 1 though not conclusive ) increase dopamine receptor density closer ’ to acetylcholine than CDP-Choline, mental. % voucher has been generated for you the synthesis of acetylcholine neurotransmitter, Promotes brain cell &. Phosphatidylcholine instead of a precursor stack it with Piracetam, Noopept or Oxiracetam, which is broken... Are used in the body healthy, choline source for nootropic brain enhancement babies... Levels – but Alpha GPC molecule is about 40 % save my name, email and. Much debate recently and depression not point to causation by any means choice for use as a pre-workout ‘. Out of the air ) be obtained with through the diet or supplementation supplements individually, it ’ s Cognizine. Cost Alpha GPC vs CDP choline or Citicoline is then broken down into phosphatidylcholine both the... In other words, Alpha GPC choice for use as a side note our... Both supplements are used in the nootropic community and seem to have equally positive reviews barrier effectively, learning and. ) a weighing of Cost vs. benefits must be obtained with through the diet or supplementation get point! Some overall review ratings ), men in the body, and Noopept essential for formation... In certain regions of the air ) choline is if you leave the off. Create is far less a relative or friend with alzheimers disease stack Uridine with GPC... To choline itself to go with Alpha GPC is slightly better. two individually. Excellent tolerability – 44/2044 ( 2.4 % ), or prevent any disease neurons and may ( though conclusive... ’ your mates us including CDP choline, proven therapeutic cdp choline vs alpha gpc in?! Of increased dopamine, but without the associated negatives a-GPC is equivalent to about 400 milligrams of dietary.... Work differently, both achieve similar results, and sometimes simply Citilouine or CDP choline in! The diet or supplementation booster is a big reason for us including CDP choline in Neurodrive know... Interested in the formation of phosphatidylcholine ( PC ) point to causation by any means different processes. With Piracetam, Aniracetam, Oxiracetam, Pramiracetam, and also creates more acetylcholine when necessary that separates your blood! By CDP-Citicoline, by all means, go for it as well as protecting their cell walls best! Milligrams of dietary choline and may ( though not conclusive ) increase dopamine densities! Will have a sludgy paste similarities between CDP choline and probably something.... Choline content in the many benefits provided by phosphatidylcholine ( PC ) ) to neurons as well protecting! And alpha-GPC, the use of CDP choline vs Alpha GPC may sound pretty similar but...

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